|
KMID : 0603820170230020104
|
|
Journal of Experimental & Biomedical Science
2017 Volume.23 No. 2 p.104 ~ p.110
|
|
|
Anti-inflammatory Effects of Aster yomena Extracts by the Suppression of Inducible Nitric Oxide Synthase Expression
|
|
Kim Ah-Yeon
Shin Hyeon-Myeong
Kim Ji-Soo
Shim Hyun-Jin
Nam Kung-Woo
Hwang Kyung-A
Youn Hyung-Sun
|
|
|
Abstract
|
|
|
|
Inflammation is a pathophysiological process that is known to be involved in numerous diseases. Microbial infection or tissue injury activates inflammatory responses, resulting in the induction of proinflammatory proteins including inducible nitric oxide synthase (iNOS). Aster yomena is used in traditional Korean remedies. Here, we investigated the effects of ethanol extracts of Aster yomena (EAY) on the expression of iNOS induced by ovalbumin (OVA), one of the major egg allergens, or lipopolysaccharide (LPS), a Toll-like receptor 4 agonist. EAY inhibited OVA- or LPS-induced NF-κB activation. EAY also suppressed OVA- or LPS-induced iNOS expression and nitrite production. These results suggest that EAY has the specific mechanism for anti-inflammatory responses and the potential to be developed as a potent anti-inflammatory and anti-allergic drug.
|
|
|
KEYWORD
|
|
|
Aster yomena , Inducible nitric oxide synthase , Ovalbumin , LPS , Inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|